Key Highlights:
- Contrave is a prescription weight loss pill combining naltrexone and bupropion.
- It helps reduce appetite and cravings by acting on hunger and reward centers in the brain.
- It is approved for adults who are overweight or obese, especially with related health conditions.
- Contrave must be used alongside a reduced-calorie diet and regular physical activity.
- The dosage increases gradually over four weeks to two tablets twice a day.
- Common side effects include nausea, headache, constipation, and sleep disturbances.
- Serious risks include seizures, high blood pressure, and psychiatric symptoms in certain individuals.
- Contrave can interact with other medications like opioids, antidepressants, MAOIs, and seizure-risk drugs.
- It is not suitable for people with uncontrolled hypertension, seizure disorders, or a history of substance misuse.
- Compared to Saxenda and Wegovy, Contrave is taken orally, which may be preferred by some users.
- In Canada, it requires a prescription and costs about $200–$250 per month without insurance.
- DooÜ offers online consultations and free delivery of Contrave through licensed Canadian providers.
Tried cutting calories? Exercising more? Still not seeing the results you hoped for? If you're struggling to lose weight despite making lifestyle changes, you're not alone. For some people, diet and exercise just aren't enough, and that's where medications like Contrave for weight loss can help. Contrave is an FDA-approved weight loss pill that’s designed to help reduce appetite and control cravings.
This guide covers everything you need to know, from how Contrave medication works, who it's intended for, possible side effects, how to take it safely, and how it compares to other weight loss options.
What is Contrave used for?

Contrave is an FDA-approved prescription medication used to support weight loss and help maintain it, especially in adults who are overweight or obese. It's intended to be used in conjunction with a reduced-calorie diet and increased physical activity, not as a standalone solution.
Doctors typically recommend Contrave for weight loss in people with a higher body mass index (BMI), particularly those with weight-related health issues like high blood pressure, high cholesterol, type 2 diabetes, low blood sugar, or a history of eating disorders. Occasionally, it may be prescribed for other conditions if your doctor feels it’s appropriate.
The medication combines naltrexone (an opioid blocker) and bupropion (an antidepressant). Together, they work on brain areas that control appetite and cravings, helping to reduce hunger and emotional eating.
Contrave medication isn’t for everyone, especially those with certain medical risks. A conversation with your healthcare provider is the best way to find out if it’s right for you.
Not sure if Contrave is right for you? Start by reviewing your weight loss options with a healthcare provider. You can also explore our guide on the best weight loss pill in Canada.
How does Contrave work?
Contrave medication helps with weight loss by targeting key brain functions that influence hunger and cravings. Here's how it works:
- Acts on the hypothalamus: This is the part of your brain that controls appetite. Contrave, an opioid antagonist, helps reduce the constant feeling of hunger, making it easier to manage portions and avoid overeating.
- Affects the brain’s reward system: Ever reach for snacks when you’re stressed or bored? Contrave works on the brain’s reward center to reduce emotional and binge eating.
- Boosts dopamine levels: Dopamine is a “feel-good” brain chemical linked to motivation and pleasure. By increasing dopamine, Contrave can lower your urge to reach for high-calorie comfort foods.
- Combines two powerful ingredients: Contrave contains naltrexone, which is often used to treat addiction, and bupropion, an antidepressant that also helps with smoking cessation. Together, they work on the brain to reduce both appetite and cravings by targeting hunger and reward pathways.
- Works best with healthy lifestyle changes: Contrave supports your weight loss efforts, but it isn’t a magic solution. It’s most effective when combined with a reduced-calorie diet, regular exercise, and long-term healthy habits.
For the best results, Contrave should always be paired with healthy lifestyle changes, such as those found in top diet trends in Canada.
How Does the Contrave Dosage Schedule Work?
When starting Contrave, the dose is increased gradually over several weeks to allow your body to adjust, thereby reducing the risk of side effects. The full maintenance dose provides a total of 32 mg of naltrexone and 360 mg of bupropion per day.
Note: The exact dosing schedule should always be determined and monitored by your healthcare provider. Please do not change your dose without consulting your healthcare provider. Always swallow the tablets whole, without crushing, splitting, or chewing them.
What Precautions Should You Take While Using Contrave?

Using Contrave safely means following a few key precautions that help lower the risk of side effects and improve results.
1. Avoid High-Fat Meals: Try not to take Contrave with high-fat foods like fried snacks, fast food, full-fat dairy, or creamy dishes. These can increase the risk of nausea and seizures.
2. Monitor Your Blood Pressure and Heart Rate: Contrave may raise both blood pressure and heart rate, especially in the early weeks. Your doctor will likely check these regularly. If you already have high blood pressure, it should be well-controlled before starting.
3. Limit or Avoid Alcohol: Drinking alcohol while on Contrave can increase the risk of side effects like dizziness, drowsiness, and even seizures. It’s best to limit or avoid alcohol altogether unless your doctor says otherwise.
4. Share Your Medical History: Before starting Contrave, let your healthcare provider know if you have a history of:
- Seizures or epilepsy
- Eating disorders such as bulimia or anorexia
- Alcohol or drug dependence
- Mood disorders like depression or bipolar disorder
- Uncontrolled high blood pressure
These conditions may increase the risk of serious side effects and could make Contrave unsafe for you.
This is one of the most important points when learning how to take Contrave correctly. Following the dosage schedule and being mindful of foods to avoid on Contrave, such as high-fat meals, helps reduce the risk of nausea and other side effects.
What Are the Common & Serious Side Effects of Contrave?

When starting Contrave, some mild side effects are fairly common. Many people experience nausea, constipation, headache, or trouble sleeping. Usually, these symptoms ease as your body adjusts to the medication.
If you notice any possible side effects of Contrave, it’s important to contact your healthcare provider right away. Most side effects are temporary, so you need to pay close attention to the unusual changes in your health, especially during the first few weeks, which is key. Here are some of the most common side effects of Contrave:
1. Gastrointestinal Issues
Digestive issues are among the most frequently reported problems with Contrave, including:
- Nausea: Many users experience this early in treatment.
- Constipation: Eating fibre-rich foods and staying hydrated can help.
- Diarrhea: Usually short-lived and tends to improve over time.
- Dry mouth: Sipping water regularly often provides relief.
These symptoms typically get better as your body gets used to the medication. If they persist or worsen, check in with your doctor.
2. Headache, Dizziness, and Sleep Issues
Headaches, eye pain, and dizziness may occur, especially while your body is adapting. To manage dizziness, try to avoid sudden movements, particularly when standing up.
Sleep problems, such as difficulty falling or staying asleep, can also happen. Taking your evening dose a bit earlier or keeping a consistent bedtime routine may help. According to Contrave reviews on public forums like Reddit, some users report initial side effects that improve over time.
One user shared, “It started working immediately for me in the first couple of weeks. The first week, I had pretty bad side effects (i.e., nausea and headaches), but after that, it leveled out. I’m still on a half dose (two pills a day) as the full dose gave me such strong migraines.”
If headaches, dizziness, or sleep troubles continue, discuss them with your healthcare provider. They can offer advice or adjust your treatment as needed.
What Are the Serious Side Effects and Risks of Contrave?
Although Contrave is generally safe, it carries some serious risks that require close monitoring. These include:
- Increased risk of seizures, especially if you have a history of seizures, eating disorders, or abrupt alcohol withdrawal
- Raised blood pressure and heart rate, particularly in those with pre-existing hypertension
- Psychiatric effects such as mood swings, anxiety, or risk of suicidal thoughts, especially in young adults
If you experience chest pain, vision changes, or unusual mood shifts, seek immediate medical attention. Regular blood pressure monitoring is important during treatment. Also, inform your healthcare provider if you or a family member has a history of psychiatric conditions or seizures before starting Contrave.
What Other Drugs Will Affect Contrave?
Contrave can interact with certain medications, which might change how well it works or increase the chance of side effects. It’s important to tell your healthcare provider about all the medicines you’re taking, including prescription drugs, over-the-counter medicines, and supplements.
Some key interactions to be aware of include:
- Opioid medications: Using Contrave with opioids can cause sudden withdrawal symptoms or dangerous effects. Contrave should never be taken if you are currently using medications for opioid dependence.
- Monoamine oxidase inhibitors (MAOIs): These must be stopped at least 14 days before starting Contrave to avoid serious reactions.
- Other drugs that increase seizure risk: Medications such as certain antidepressants or antipsychotics may raise your risk of seizures when taken with Contrave.
- Diabetes and blood pressure medications: Contrave may affect blood sugar and blood pressure levels, so dosages of these drugs might need adjusting.
Always consult your healthcare provider before starting or stopping any medications while using Contrave to ensure safe and effective treatment.
What Health Conditions Should You Discuss With Your Healthcare Provider Before Taking Contrave?
Before starting Contrave, it’s important to have an open conversation with your healthcare provider about your medical history. Certain health conditions can affect how safe or effective Contrave will be for you.
Be sure to mention if you have a history of:
- Kidney disease or liver problems
- Heart disease or high blood pressure
- Psychiatric disorders such as depression or anxiety
- Diabetes, as weight loss may impact blood sugar levels and require medication adjustments
- Past head injuries or glaucoma
- A history of drug or alcohol dependence
Sharing this information helps your healthcare provider identify any risks and tailor your treatment plan to keep you safe while using Contrave. Regular monitoring and clear communication are key to managing your health effectively during weight loss treatment.
How Does Contrave Compare to Other Weight Loss Medications?
Contrave is one of several prescription options for weight management. What sets it apart is its unique way of targeting both appetite and cravings. Unlike some alternatives like Saxenda and Wegovy, which are injectable and work mainly by affecting satiety hormones, Contrave comes in tablet form.
This makes it a preferred choice for those who want an oral medication or haven't found success with other treatments. Each medication has its own benefits and risks, so it's important to discuss with your healthcare provider which option best fits your health needs and lifestyle.
Want to learn more? Read about weight loss injections and how effective they are.
| Feature | Contrave | Saxenda | Wegovy |
| Form | Oral tablets | Injection | Injection |
| Active Ingredients | Naltrexone + Bupropion | Liraglutide | Semaglutide |
| How It Works | Reduces appetite and cravings by targeting brain pathways | Mimics satiety hormones to reduce hunger | Mimics satiety hormones to reduce hunger |
| Administration Frequency | Twice daily | Once daily | Once weekly |
| Common Side Effects | Nausea, headache, constipation, insomnia | Nausea, vomiting, diarrhea | Nausea, vomiting, diarrhea |
| Suitable For | Adults preferring oral medication or who did not respond to other meds | Adults are comfortable with daily injections | Adults are comfortable with weekly injections |
Who Should Not Take Contrave?
Certain individuals should avoid taking Contrave with uncontrolled high blood pressure, bipolar disorder, seizure disorders, eating disorders, or significant alcohol/substance abuse histories. Additionally, pregnant or breastfeeding women and those using monoamine oxidase inhibitors (MAOIs) within 14 days should not use this medication.
Looking to begin Contrave treatment in Canada?
How To Store Contrave?
Keep Contrave medication in a cool, dry place at room temperature (20°C to 25°C or 68°F to 77°F). Make sure the bottle is tightly closed and stored away from moisture, heat, and direct sunlight. Avoid keeping it in the bathroom or near the kitchen sink.
Keep out of reach of children and pets. Do not use Contrave past its expiration date, and if you’re unsure how to dispose of unused medication, ask your pharmacist for proper guidance and refer to the medication guide for more information.
Want Contrave in Canada? DooÜ Makes It Easy
Getting started with Contrave in Canada doesn't have to be complicated. With DooÜ, the entire process, from consultation to delivery, is simple, secure, and fully online. You'll connect with licensed Canadian doctors who review your health profile and, if appropriate, provide a prescription for Contrave medication without the need for an in-person visit.
Once approved, your medication is shipped straight to your door through trusted partner pharmacies. Delivery is fast, discreet, and completely free. DooÜ also works with most major Canadian insurance providers, helping you get coverage or find cost-saving options if you're paying out-of-pocket.
Whether you're just starting your weight loss journey or looking for a more convenient way to access treatment, DooÜ takes care of everything, so you can focus on achieving your results.
Have questions or ready to begin?
Final Words
Losing weight isn’t always as simple as eating less and moving more. For some people, Contrave medication can offer meaningful support by helping reduce cravings and emotional eating, making it easier to stay on track.
That said, Contrave isn’t a quick fix. It works best when combined with long-term lifestyle changes and regular guidance from a healthcare provider. With the right support system and a clear plan, it can be a valuable part of a successful weight loss journey.
If you’re considering trying Contrave, consult your doctor to determine if it aligns with your health goals and needs. Sustainable weight loss is possible, and you don't have to do it alone.
Frequently Asked Questions
Is Contrave available in Canada?
Contrave is available in Canada, but obtaining it requires a prescription and prior authorization from a healthcare provider. Local availability may vary by pharmacy, so it's essential to check with your pharmacist for specific stock and ordering options if needed.
How much is Contrave in Canada?
In Canada, the cost of Contrave varies by pharmacy but typically ranges from $200 to $250 for a month's supply without insurance. It's advisable to check with local pharmacies, healthcare providers, or telehealth platforms like DooÜ for exact pricing and potential discounts or savings programs.
What should I know about Contrave before using it?
Contrave helps with weight loss by reducing appetite and cravings, but it’s not for everyone. Before starting, tell your doctor if you have liver problems, as Contrave may increase the risk of liver damage. It may also cause side effects, such as nausea, headache, or trouble sleeping. Avoid it if you have a history of seizures, high blood pressure, or are taking opioids. Regular check-ups help ensure safe use.
Is Contrave an antidepressant?
Contrave is not classified as an antidepressant; it combines bupropion, which has antidepressant properties, and naltrexone, typically used for addiction. Its primary purpose is weight loss management rather than treating depression or anxiety disorders. Always consult a healthcare provider for personalised information.
What are the benefits and drawbacks of taking Contrave?
Contrave offers benefits like weight loss and reduced cravings, potentially leading to improved metabolic health. However, drawbacks include possible side effects such as nausea, dark urine, headache, or increased blood pressure, and possibly symptoms of liver problems. It's essential to weigh these factors with a healthcare provider before starting treatment.
What should I do if I miss a dose of Contrave?
If you miss a dose of Contrave, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and resume your regular schedule. If you have concerns about your dosage or any reactions, always consult your healthcare provider for personalised medical help and advice.
When does Contrave start working?
Contrave typically begins to show body weight loss results within 4 to 12 weeks of consistent use, depending on individual factors like adherence to lifestyle changes and dosage. After a few months of treatment, regular follow-ups with a healthcare provider can help assess progress and adjust the treatment plan if needed.
How long should you wait to eat after taking Contrave?
After taking Contrave, it’s generally recommended to wait at least one hour before eating. This allows the medication to be absorbed effectively into your system, maximising its effectiveness in aiding weight loss while minimising potential gastrointestinal discomfort. Always consult your healthcare provider for personalised medical advice.
Are there any long-term studies on the safety and effectiveness of Contrave?
Yes. Clinical trials and follow-up studies up to one year show Contrave can support weight loss and improve related health markers when combined with lifestyle changes. Longer-term safety beyond a year is still being studied.







































































